This means Xbox 360, Xbox One, and Xbox Series S/X (and many other third party controllers). This mod will work with any controller that uses the XInput protocol for button inputs to Windows.
The MP version to play MP, they cannot be both installed at the same time. You will need to uninstall this mod and install Multiplayer does not work while this mod is installed This mod will scale up interfaces to make them appear the same size as they do on Xbox. The power wheel for standard keyboard and mouse is changed to the ones for controllers and optimizes a few interfaces for PC. This mod brings the full power wheel from the Xbox version of the game into PC along with native controller support in the interfaces for Xbox 360 controllers.
Mass Effect 3 Native Controller Support for SinglePlayer